Ahead of the Bell: US Industrial Production

WASHINGTON (AP) -- U.S. industrial production likely picked up a bit last month, although factory output probably stayed weak. Many companies remain worried about looming tax increases and may have further delayed purchases of machinery and equipment.

Economists forecast that output at the nation's factories, mines and utilities rose 0.3 percent in November from October, according to a survey by FactSet. That would offset most of the 0.4 percent decline in October.

The Federal Reserve will release the report at 9:15 a.m. EST Friday.

Factory output, the most important component, tumbled 0.9 percent in October. Part of the decline was blamed on Superstorm Sandy, which disrupted some factories in the Northeast. Economists expect the storm had less impact on the November data.

Still, many companies have also held off on big purchases since spring because they are worried about the "fiscal cliff". That's the combination of tax increases and spending cuts that are set to take effect in January if President Barack Obama and Republican lawmakers can't reach a budget deal before then.

Fears of the fiscal cliff continued to weigh on factory activity in November, other data showed.

U.S. manufacturing activity shrank in November to the slowest pace since July 2009, according to a closely watched index of manufacturing activity compiled by the Institute for Supply Management.

Economists say the economy is growing in the current October-December quarter at an annual rate below 2 percent. That would be slower than the 2.7 percent growth rate in the July-September quarter and too weak to rapidly lower the unemployment rate.

The job market is making steady gains. Employers added 146,000 jobs in November. That's about the same as the average monthly gain of 150,000 in the past year.

The unemployment rate fell to 7.7 percent ? a four-year low ? from 7.9 percent in October. But the decline occurred mostly because more people without jobs gave up looking for work. The government counts people without jobs as unemployed only if they're actively seeking one.

High unemployment and weak economic growth prompted the Federal Reserve Wednesday to make a major change in its guidance of future interest rate hikes. The Fed said it plans to keep the benchmark short-term interest rate near zero until unemployment falls to at least 6.5 percent, as long as inflation stays low.

It was the clearest sign yet that they will keep rates super-low even after unemployment falls further and the economy picks up. The Fed also said it would continue purchasing $85 billion in Treasury bonds and mortgage-backed securities each month in an effort to push down longer-term interest rates.

Source: http://news.yahoo.com/ahead-bell-us-industrial-production-103821075.html

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Picture your Windows 7 desktop ? Business Management Daily ...

Q. I want my own photos as my desktop background. How do I do that?

A. If you use Windows 7 and want to see your own photos rotating on the desktop, you can make this change easily.

First, get all the pictures you?d like to see on your desktop in a single folder. I recommend simply having a folder in your Picture library called My Desktop. Copy or move your pictures to this folder.

Now, right-click on the desktop and choose Personalize. Choose Desktop Background from the bottom of the dialog box. Click the Browse to find, and select your picture folder.

You can check and uncheck the photos you?d like to see in rotation and at what frequency you?d like to rotate them.

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We believe great content should be read and passed around. After all, knowledge IS power. And good business can become great with the right information at their fingertips. If you'd like to share any of the insightful articles on BusinessManagementDaily.com, you may republish or syndicate it without charge.

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Rock legends take to New York stage for storm Sandy victims

NEW YORK (Reuters) - Bruce Springsteen, Jon Bon Jovi and the Rolling Stones joined with actors and comedians in headlining a benefit concert on Wednesday for victims of Superstorm Sandy, which six weeks ago devastated scores of communities along the coastline of the U.S. northeast coastline.

The celebrity-packed "12-12-12" concert at New York's Madison Square Garden stretched on for nearly five hours, and organizers said it was distributed to nearly 2 billion people worldwide through television feeds, radio and online streaming.

"How do I begin again? My city's in ruins," Springsteen sang to the packed crowd. He was joined by fellow New Jersey native Jon Bon Jovi for "Born to Run," ushering in a night of musical duets.

Next up, Pink Floyd's Roger Waters performed alongside Pearl Jam's Eddie Vedder, and later Paul McCartney jammed with the surviving members of "Nirvana."

"This has got to be the largest collection of old English musicians ever assembled in Madison Square Garden," Mick Jagger told the crowd. The Stones, in the midst of a brief U.S. tour, performed "You Got Me Rocking" and "Jumpin' Jack Flash."

Chris Martin of Coldplay jokingly suggested audience members should calculate the average age of the night's performers and agree to donate that much. "And I think you'll raise billions," he said.

At the end of the concert, R&B singer Alicia Keys closed the show with "Empire State of Mind."

To help with the fundraising, celebrities such as Kristen Stewart, Jake Gyllenhaal, Chelsea Clinton and Billy Crystal took part in a telethon during the concert.

Comedian Adam Sandler took the stage for a Sandy-themed spoof on Leonard Cohen's "Hallelujah," rhyming the title with "Sandy, Screw Ya!"

Backstage, actress Susan Sarandon recounted losing power in her New York home but said that was a small hardship compared with the real victims who lost their homes.

Steven Van Zandt, guitarist of the E Street Band, scolded "the oil companies" and "Wall Street guys" for not doing more to help.

"Even with the music business not what it used to be ... we are proud to be here," he said.

The concert was broadcast live on television, radio, movie theaters, on Facebook and iHeartRadio, and streamed on digital billboards in New York's Times Square, London and Paris.

EXPANDING FUNDRAISING'S REACH

More than 130 people were killed when Sandy pummeled the East Coast of the United States in October. Thousands more were left homeless as the storm tore through areas of New York, New Jersey and Connecticut, causing billions of dollars in damage.

Throughout the show, celebrities shared memories of growing up in New York City or the Jersey Shore, and offered shout-outs to first responders.

"Watching my hometown get pummeled was devastating to watch," said actor-comedian Crystal, who grew up on Long Beach, Long Island. "It's a helpless feeling of what's in store for us maybe in the future."

As the show neared its finale, organizers said it had raised $30 million from corporate sponsors, ticket sales and donations. The total raised from called-in pledges will take more time to calculate, said a spokesman for the Robin Hood foundation, the concert's major beneficiary.

Donations raised from the concert produced by Clear Channel Entertainment and the Weinstein Co, will all go to the Robin Hood Relief Fund, which will provide money and materials to groups helping people hardest hit by the storm.

New Jersey is expected to take 40 percent of the total, while the rest will be divided up between New York City, Long Island and Connecticut.

(Additional reporting by Piya Sinha-Roy; Editing by Jill Serjeant, Patricia Reaney and Peter Cooney)

Source: http://news.yahoo.com/rock-legends-york-stage-storm-sandy-victims-015600211.html

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The Decades That Invented the Future, Part 8: 1971-1980

Since 2007, Wired.com’s This Day In Tech blog has reflected on important and entertaining events in the history of science and innovation, pursuing them chronologically for each day of the year. Hundreds of these essays have now been collected into ...

Source: http://feedproxy.google.com/~r/GearFactor/~3/hCF7ptVWjzA/

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Samsung strategy chief: our devices need to work better together

When Samsung is currently ruling the roost in mobile technology, you'd think the company's Chief Strategy Officer would exhibit some (possibly deserved) bluster. Not so: the executive in question, Young Sohn, tells the MIT Technology Review that Samsung has a long way to go before its products work in perfect harmony. While he's proud of the hardware in isolation, he believes a truly unified ecosystem is "really critical" in the long term. He sees Apple as ahead in this area, although he's arguing for an open approach instead of keeping everything in-house like they do in Cupertino. Partly to that end, the recently hired CSO is based in Menlo Park, not Seoul -- a step that should spot valuable technology early on and coordinate with San Francisco Bay Area startups that are big on the cloud, mobile platforms and other areas that compliment Samsung's plans. We don't know how long it will take before our Galaxy S III is in effortless sync with a similarly-branded TV, but it's good to know their mutual creator won't be resting on its laurels.

Filed under: Cellphones, Home Entertainment, Internet, Samsung

Comments

Via: The Verge

Source: MIT Technology Review

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/EhgKw4u68a8/

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Vice Chancellor of Marketing and Communications - HigherEdJobs

Requisition # P1213-26

Position Title: Vice Chancellor of Marketing & Communications
Department: Marketing
Posting type: Open to internal and external applicants.
Salary: Salary is commensurate with experience and qualifications
Employment Status: Full time

Description of Responsibilities: The Vice Chancellor of Marketing and Communications provides vision and leadership to a strategic, results-oriented team responsible for planning and executing marketing and communication initiatives to advance Palmer's mission and priorities. This person will develop and execute marketing, branding, public relations, and communications strategies to internal and external audiences, proactively identifying and promoting services and programs to enhance Palmer's image among key audiences. This person will take lead in the development of marketing and communications efforts aligning Palmer's strategic plan with the demands of a variety of internal constituencies through a centralized cohesive marketing and communications plan and effort.

Position Qualifications Required: Bachelor's degree required, Master's degree preferred; Ten years of experience in middle or senior management is required, with three to five years of experience in marketing and communications planning; Minimum of five years of supervisory experience required; Or equivalent combination of education and experience.

The ideal candidate will be creative, entrepreneurial, well versed in the trends in marketing and segmentation for higher education, with a particular focus on emerging technology for print and electronic campaigns

Application Deadline: Applications will be accepted until the position is filled. Please send cover letter, resume and salary history to:

Human Resources
Palmer College of Chiropractic, Davenport Campus
1000 Brady Street
Davenport, IA 52803
Fax to 563-884-5802
E-mail: hr.dept.ia@palmer.edu

EEO/AA/HV employer. Applicants selected for interviews who may require access
accommodations are encouraged to contact the Human Resources Office.

Source: http://www.higheredjobs.com/details.cfm?JobCode=175701481

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U.S. backs Syrian rebels ahead of conference

MARRAKECH, Morocco (AP) ? A Syrian opposition spokesman called for "real support" and not just recognition on Wednesday, hours after the U.S. declared that the new Syrian opposition coalition was the "legitimate representative" of its country's people.

Speaking as the fourth meeting of the "Friends of the Syrian People" opened in the Moroccan city of Marrakech, Walid al-Bunni called on the more than a hundred delegates from Europe and the Gulf countries to provide something concrete to help in their battle against Syrian President Bashar Assad's regime.

"Recognition is nice, but we need real support," said Walid al-Bunni, a spokesman for the newly formed Syrian National Coalition as the conference began. "I will be happy after the conference if we have something for the Syrian people."

The U.S. move, announced by President Barack Obama late Tuesday, follows that of France and the U.K.

The Syrian National Coalition, formed in November during a conference in Doha, Qatar, has been calling for increased international support, including military material for opposition forces battling the regime of Bashar Assad in Syria for nearly two years.

The U.S. and its British allies are not, however, expected to approve military aid, in part over fears of al-Qaida linked rebel units operating in the country. There are also no representatives of the Syrian rebel forces at the conference.

John Wilks, the British special representative to the Syrian opposition, explained that Wednesday's event was neither a donor conference nor a military aid event but rather an effort to set up opposition institutions so that they could effectively use future aid in a credible manner to administer the areas they control.

"The key point is that they are setting up institutions and money is coming, so it's a better situation than three months ago ? they are happy, we are happy," he said before the conference began.

He said so far Britain had earmarked 50 million pounds ($80 million) of humanitarian aid and 7 million pounds ($11.2 million) non-humanitarian including communications equipment, training and office supplies ? but no plans for now for military aid.

"There are big issues concerning legality ? intervening in a civil war to overthrow a government is a difficult proposition, to put it mildly," he said.

Obama's announcement follows his administration's blacklisting of a militant Syrian rebel group with links to al-Qaida. That step is aimed at blunting the influence of extremists amid fears that the regime may use or lose control of its stockpile of chemical weapons.

The U.S. had been leading international efforts to prod the fractured Syrian opposition into coalescing around a leadership that would represent all of the country's factions and religions. Yet it had held back from granting recognition to the group until it demonstrated that it could organize itself in credible fashion.

In particular, Washington had wanted to see the group set up smaller committees that could deal with specific immediate and short-term issues, such as governing parts of Syria under their control and putting in place institutions to address the needs of people once Assad is ousted. Some of those committees could form the basis of a transitional government.

U.S. Secretary of State Hillary Rodham Clinton was expected to attend the conference, but cancelled following an illness and will be represented by Deputy Secretary of State for the Middle East, William Burns.

Russian Foreign Minister Sergey Lavrov said Wednesday the recognition contradicted earlier international agreements that foresee the "commencement of an all-Syria dialogue" that would include all sides of the conflict, in which more than 40,000 people have died so far.

Source: http://news.yahoo.com/us-backs-syrian-opposition-ahead-conference-084043885.html

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Study paves way to design drugs aimed at multiple protein targets at once

Dec. 12, 2012 ? An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.

This accomplishment, described in the Dec. 13, 2012 issue of the journal Nature, may prove invaluable for developing drugs to treat many common human diseases such as diabetes, high blood pressure, obesity, cancer, schizophrenia, and bi-polar disorder.

These disorders are called complex diseases because each have a number of genetic and non-genetic influences that determine susceptibility, i.e., whether someone will get the disease or not.

"In terms of the genetics of schizophrenia we know there are likely hundreds of different genes that can influence the risk for disease and, because of that, there's likely no single gene and no one drug target that will be useful for treating it, like other common complex diseases," said study co-leader, Brian L. Roth, MD, PhD, Michael J. Hooker Distinguished Professor of Pharmacology in the UNC School of Medicine, professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy, and director of the National Institute of Mental Health Psychoactive Drug Screening Program.

In complex neuropsychiatric conditions, infectious diseases and cancer, Roth points out that for the past 20 years drug design has been selectively aimed at a single molecular target, but because these are complex diseases, the drugs are often ineffective and thus many never reach the market.

Moreover, a drug that acts on a single targeted protein may interact with many other proteins. These undesired interactions frequently cause toxicity and adverse effects.

"And so the realization has been that perhaps one way forward is to make drugs that hit collections of drug targets simultaneously. This paper provides a way to do that," Roth said.

The new way involves automated drug design by computer that takes advantage of large databases of drug-target interactions. The latter have been made public through Roth's lab at UNC and through other resources.

Basically, the researchers, also co-led by Andrew L. Hopkins, PhD in the Division of Biological Chemistry and Drug Discovery, College of Life Sciences, at the University of Dundee, in Scotland, used the power of computational chemistry to design drug compounds that were then synthesized by chemists, tested in experimental assays and validated in mouse models of human disease.

The study team experimentally tested 800 drug-target predictions of the computationally designed compounds; of these, 75 percent were confirmed in test-tube (in vitro) experiments.

Drug to target engagement also was confirmed in animal models of human disease. In a mouse model of attention deficit hyperactivity disorder (ADHD), mice missing a particular dopamine receptor engage in recurrent aberrant behaviors similar to what is seen in ADHD: distractibility and novelty seeking. "We created a compound that was predicted to prevent those recurrent behaviors and it worked quite well," Roth said.

The researchers then tested the compound in another mouse model where a particular enzyme for a brain neuropeptide is missing. Distractibility and novelty seeking also are behavioral features in these animals. And the drug had the same effect in those mice.

The new drug design process includes ensuring that compounds enter the brain by crossing the blood-brain barrier. These, too, were tested successfully in live animals.

According to Roth, pharmaceutical company chemists had suggested that the objective of a drug hitting multiple targets simultaneously is impossible and unlikely to succeed. "Here we show how to efficiently and effectively make designer drugs that can do that."

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---

Story Source:

The above story is reprinted from materials provided by University of North Carolina Health Care.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. J?r?my Besnard, Gian Filippo Ruda, Vincent Setola, Keren Abecassis, Ramona M. Rodriguiz, Xi-Ping Huang, Suzanne Norval, Maria F. Sassano, Antony I. Shin, Lauren A. Webster, Frederick R. C. Simeons, Laste Stojanovski, Annik Prat, Nabil G. Seidah, Daniel B. Constam, G. Richard Bickerton, Kevin D. Read, William C. Wetsel, Ian H. Gilbert, Bryan L. Roth, Andrew L. Hopkins. Automated design of ligands to polypharmacological profiles. Nature, 2012; 492 (7428): 215 DOI: 10.1038/nature11691

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/deFlpBdvRVc/121212134058.htm

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Guinea commission sets May 13 date for elections

CONAKRY, Guinea (AP) ? Guinea's national electoral commission says it plans to hold long-awaited legislative elections in May.

Commission President Bakary Fofana made the announcement on national television late Tuesday. But opposition spokesman Mouctar Diallo expressed disapproval, calling the May 13 date a unilateral decision by the commission president.

The electoral commission's composition has been a source of tension in this West African country long plagued by dictatorship and strongman rule.

In 2010, Guinea succeeded in holding its first democratic presidential election since winning independence from France in 1958.

It now has a democratically elected president but not a functioning parliament because of the failure to organize legislative elections.

Source: http://news.yahoo.com/guinea-commission-sets-may-13-date-elections-132249957.html

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Ancient tsunami caused long-term ecosystem change in the Caribbean

Dec. 12, 2012 ? A detailed analysis of sediments from the island of Bonaire in the Caribbean presents convincing evidence for an extraordinary wave impact dating back some 3,300 years, even though no historical records of tsunamis exist for this island. Of particular interest are the consequences this large wave impact had on the island's ecosystem. The sediments studied by the scientists suggested that this tsunami entirely changed the coastal ecosystem and sedimentation patterns in the area.

The work by Dr. Max Engel and colleagues, from the University of K?ln in Germany, is published online in Springer's journal, Naturwissenschaften -- The Science of Nature.

The Caribbean region is highly vulnerable to coastal hazards, including tropical cyclones, earthquakes, volcanoes, and tsunamis. Even though the island of Bonaire has not experienced a tsunami during the past 500 years, which is the period of historical documentation, overwash deposits from a coastal lagoon provide evidence for at least one such event in prehistory.

Engel and colleagues investigated sediment cores from Washington-Slagbaai National Park. They looked specifically at grain size distribution, carbonate content, organic matter, magnetic susceptibility and fauna. Their analyses showed that the sediments had criteria typically linked with tsunami deposits, consistent with a tsunami with a maximum age of 3,300 years.

The authors conclude: "This single catastrophic event is of long-term ecological significance. Formation of a barrier of coral rubble was triggered by the tsunami separating a former inland bay from the open sea and turning it into a highly saline lagoon which persists until today. Further studies of the geology of tsunamis, using well-dated deposits, are required over the entire Caribbean to reconstruct reliable patterns of magnitude, frequency and spatial occurrence of tsunami events and their environmental impact."

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Story Source:

The above story is reprinted from materials provided by Springer Science+Business Media, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Max Engel, Helmut Br?ckner, Sascha F?rstenberg, Peter Frenzel, Anna Maria Konopczak, Anja Scheffers, Dieter Kelletat, Simon Matthias May, Frank Sch?bitz, Gerhard Daut. A prehistoric tsunami induced long-lasting ecosystem changes on a semi-arid tropical island?the case of Boka Bartol (Bonaire, Leeward Antilles). Naturwissenschaften, 2012; DOI: 10.1007/s00114-012-0993-2

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/7z085niVRbI/121212092821.htm

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Autopsy results on nurse in hoax due out Thursday

Husband of the late nurse Jacintha Saldanha, Benedict Barboza arrives at the Houses of Parliament in central London with daughter Lisha, 14, and son Junal, 16, for a meeting with a British Member of Parliament about Jacintha Saldanha's death Monday Dec, 10, 2012. Saldanha was found dead in central London on Friday, Dec. 7, 2012. Australian radio hosts managed to impersonate Queen Elizabeth II and Prince Charles and received confidential information about the Duchess of Cambridge's medical condition, in a hoax phone call to the King Edward VII hospital where the pregnant Duchess was staying and which was broadcast on-air. The controversial prank took a dark twist three days later with the death of nurse Saldanha, a 46-year-old mother of two, who was duped by the DJs despite their Australian accents.(AP Photo /Anthony Devlin/PA) UNITED KINGDOM OUT

Husband of the late nurse Jacintha Saldanha, Benedict Barboza arrives at the Houses of Parliament in central London with daughter Lisha, 14, and son Junal, 16, for a meeting with a British Member of Parliament about Jacintha Saldanha's death Monday Dec, 10, 2012. Saldanha was found dead in central London on Friday, Dec. 7, 2012. Australian radio hosts managed to impersonate Queen Elizabeth II and Prince Charles and received confidential information about the Duchess of Cambridge's medical condition, in a hoax phone call to the King Edward VII hospital where the pregnant Duchess was staying and which was broadcast on-air. The controversial prank took a dark twist three days later with the death of nurse Saldanha, a 46-year-old mother of two, who was duped by the DJs despite their Australian accents.(AP Photo /Anthony Devlin/PA) UNITED KINGDOM OUT

LONDON (AP) ? London police say the result of an autopsy on the nurse involved in a prank call for information about the former Kate Middleton's hospital stay will be revealed Thursday.

Scotland Yard said Wednesday the cause of Jacintha Saldanha's death will not be released until a Westminster Coroner's Court hearing.

Saldanha took the call when two Australian disc jockeys rang up the hospital where the Duchess of Cambridge was being treated for severe morning sickness. The DJs, who were impersonating Queen Elizabeth II and Prince Charles, later broadcast the call.

Saldanha was found dead Friday. Although police have made no connection between Saldanha's death and the prank call, people from London to Sydney have been making the assumption she died because of stress from the call.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-12-12-Britain-Royal%20Pregnancy-Hoax/id-584fc43d0ae1433d98865c91b2982200

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Nike+ Accelerator program to boost innovation in self-improvement

Nike announced yesterday that its first Nike+ Accelerator program targeted at companies interested in leveraging Nike+ tech like the Nike Fuel Band to explore creating mobile products or services that will inspire athletes for better fitness and healthier living.

To begin in March, Nike in association with TechStars has launched the 3 month accelerator to draw 10 organisations in an effort to develop new health and athletic mobile technology by providing them with software tools and direct interaction with tech industry mentors like Nike?s Vice President of Digital Sport Stefan Olander, TechStars founder David Cohen, and Foursquare co-founder Naveen Selvadurai.

?

TechStars has successfully carried out over 15 intensive, mentor-driven, 3-month accelerator programs which has raised $275 million in venture capital for its graduates in the six years they have been using this model. They will develop the program centered around the Nike+ API and SDK (Software Development Kit) to inspire innovation ?across a broad range of activity and health goals including training, coaching, gaming, data visualization and quantified self.?

?

?

Nike is accepting applications for the accelerator program now, with the course intended to run ?from March until June. Upon completion of ?the program, graduates will be able to showcase their Nike+-inspired tech to investors, and will also get to spend 2 days ?in the field?- one day at Nike?s World Headquarters in Portland, Oregon, and another in Silicon Valley.

?

Nike+ creates athletic fitness hardware and software for self-enrichment purposes, like the Fuel Band, Nike Sportwatch GPS, and the Nike+ fitness tracker app for iOS and Android. Products conceptualised at this accelerator will have a similar focus sports, coaching, and exercise.

?

Source: http://www.mobile88.com/news/read.asp?file=/2012/12/11/20121211111802&phone=nike-nike+-accelerator-techstars

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